MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. It has been studied in laboratory models involving cellular energy metabolism, metabolic homeostasis, stress-response signaling, and AMP-activated protein kinase (AMPK) pathways.
Structure: 16-amino-acid peptide
Amino-Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂ (free-peptide form)
Research Focus: Mitochondrial signaling, cellular metabolism, and metabolic-stress responses
Research Use Only: Not intended for human or veterinary use.