PT-141, also known as bremelanotide, is a synthetic cyclic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). It activates several melanocortin receptor subtypes and has been studied in research involving melanocortin signaling and related neural pathways.
Structure: Synthetic cyclic heptapeptide
Peptide Sequence: Ac-Nle-cyclo-(Asp-His-D-Phe-Arg-Trp-Lys-OH)
Molecular Formula: C₅₀H₆₈N₁₄O₁₀ (free-base form)
Molecular Weight: Approximately 1,025.2 g/mol
Receptor Activity: Melanocortin receptor agonist, including MC1R, MC3R, MC4R, and MC5R
Research Focus: Melanocortin-receptor signaling and associated neural pathways
Research Use Only: Not intended for human or veterinary use.